Previously funded Aspergillus projects
DEVELOPING NOVEL TREATMENTS FOR THE MOST SERIOUS CGD INFECTION: ASPERGILLUS
Professor Tom Rogers, Dr Elaine Bignell, Dr Ken Haynes & Professor Arst Herb.
Imperial College Faculty of Medicine, London
£181,587 over 32 months, ended in 2004
This project studied the way in which the Aspergillus family of fungi can adapt to changes in their growth environment and if this adaptive mechanism could be an important factor in their ability to cause disease in CGD. The group identified part of a pH dependent protein, which allows growth adaptation to acid and alkaline conditions, as a potential drug anti-fungal drug target. Importantly, the group found that by manipulating specific components of the pH dependent genes they could increase and decrease the extent of the Aspergillosis infection induced by the fungi. These encouraging results may lead to the development of new antifungal drugs and has given new insights into invasive aspergillosis that should benefit the treatment of CGD patients in the future.
IMPORTANT NOTE :
The information contained on this website is intended only as a guideline, not as a substitute for medical advice. Always consult your doctor if you or your child has any CGD symptoms or concerns.
© 2001-2007 The Chronic Granulomatous Disorder (CGD) Research
Trust
Registered Charity No. 1003425 email:cgd@cgdrt.co.uk
The CGD Research Trust is a member of the Association of Medical Research Charities (AMRC), the Genetic Interest Group (GiG) and an associate member of the International Patient Organisation of Primary Immunodeficiencies (IPOPI)
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