Our share of proceeds from the last seven Jeans for Genes campaigns has enabled us to fund research projects at different Institutions, all centres of excellence. The Trust wants to encourage close collaboration between researchers, nationally and internationally, and fund key areas of research that target specific problems that affect CGD patients.
Gene Therapy
Our primary aim is to fund work that will result in a safe and effective cure for CGD. A large part of our research income is therefore given to projects that are developing gene therapy procedures that will replace the defective gene in the bone marrow of patients with CGD with a correctly functioning gene. This will mean that CGD patients will have an immune system that will work correctly and be able to fight infections.
Find out more about Gene Therapy and the projects we fund in this area
Inflammation
Another target area for Trust funding is research into understanding why the faulty gene in CGD causes inflammatory problems such as abscesses. The aim of these projects is to find better ways of treating inflammation by a greater understanding of what happens at the cellular level.
Find out more about projects concerning Inflammation in CGD
Aspergillus
Infections caused by the spores from the fungus Aspergillus can cause serious problems in CGD because such infections are invasive, increase rapidly and are often difficult to eradicate. The Trust supports work that will advance the development of better anti-fungal drugs.
Find out more about projects on fighting Aspergillus infections in CGD
Enzyme Defect
In CGD, parts of the enzyme NADPH oxidase are either missing or defective. It is this protein complex that is responsible for generating a respiratory burst that helps kill bacteria and fungi.
In order to understand how the genetic mutations in CGD affect the working of this important protein several research projects are funded that examine in great detail how the components of this complex enzyme work together.
Find out more about projects on understanding the enzyme affected in CGD
The UK and European CGD Registries
The aim of these projects is to provide a central source of information about CGD in the UK and Europe. The Registries will provide accurate information on the incidence of CGD in the general population, document the problems and lifestyles of patients and their families and help determine if there is any correlation between genetic variation and the pattern of illnesses seen in the disorder. This work is still ongoing with the collection of data from new patients that are diagnosed with CGD.
Find out more about the aims and results of the CGD Registries
IMPORTANT NOTE :
The information contained on this website is intended only as a guideline, not as a substitute for medical advice. Always consult your doctor if you or your child has any CGD symptoms or concerns.
© 2001-2007 The Chronic Granulomatous Disorder (CGD) Research Trust
Registered Charity No. 1003425 email:cgd@cgdrt.co.uk
The CGD Research Trust is a member of the Association of Medical Research Charities (AMRC), the Genetic Interest Group (GiG) and an associate member of the International Patient Organisation of Primary Immunodeficiencies (IPOPI)
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